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Professionals are divided over best care for hip fracture patients, latest audit results show

The latest report from the Falls and Fragility Fracture Programme (FFFAP) National Hip Fracture Database (NHFD) shows that just over half of patients are receiving pain relieving anaesthetic (known as a 'nerve block') as part of their care for hip fracture. The National Hip Fracture Database Anaesthesia Sprint Audit of Practice (ASAP) results, published today (31 March 2014), show that 56% of hip fracture patients receive a peri-operative nerve block for pain relief and 44% of patients do not.



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Chemotherapy may be assisted by natural plant compounds

Researchers at Plant & Food Research have identified plant compounds present in carrots and parsley that may one day support more effective delivery of chemotherapy treatments.Scientists at Plant & Food Research, working together with researchers at The University of Auckland and the National Cancer Institute of The Netherlands, have discovered specific plant compounds able to inhibit transport mechanisms in the body that select what compounds are absorbed into the body,and eventually into cells. These same transport mechanisms are known to interfere with cancer chemotherapy treatment.



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Cells measure surface area to know when to divide

One of the scientists who revealed how plants "do maths" can now reveal how cells take measurements of size. Size is important to cells as it determines when they divide.In a paper published in eLife, Professor Martin Howard from the John Innes Centre and colleagues from the US, Germany and Singapore discovered that cells measure their surface area using a particular protein, cdr2p. The finding challenges a previous model suggesting that another protein called pom1p senses a cell's length.



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First small left ventricular assist device implant for young patient

"Today, we're going to make history," said 18-year-old Eric Ramos on the day UT Southwestern Medical Center doctors operated on his ailing heart. Eric, who has Duchenne muscular dystrophy, is one of only three patients in the United States with the condition to receive a battery-operated left ventricular assist device (LVAD) to keep his weakening heart pumping blood through his body. He is the first patient in the country to be given a specific, smaller LVAD, which means doctors would not need to manipulate his diaphragm, which could compromise his already limited pulmonary function.



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Researchers explore function of cancer-causing gene

Developmental biologists at the University of Georgia are discovering new roles for a specific gene known as Max's Giant Associated protein, or MGA. A little studied protein, MGA appears to control a number of developmental processes, and also may be connected to cancer development.The researchers detail their findings in a paper published recently in the journal Developmental Cell.



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Key player identified in motor neuron death in Lou Gehrig's disease

Amyotrophic lateral sclerosis, also known as Lou Gehrig's disease, is marked by a cascade of cellular and inflammatory events that weakens and kills vital motor neurons in the brain and spinal cord. The process is complex, involving cells that ordinarily protect the neurons from harm. Now, a new study by scientists in The Research Institute at Nationwide Children's Hospital points to a potential culprit in this good-cell-gone-bad scenario, a key step toward the ultimate goal of developing a treatment.



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Cancer biologists link tumor suppressor gene to stem cells

Just as archeologists try to decipher ancient tablets to discern their meaning, UT Southwestern Medical Center cancer biologists are working to decode the purpose of an ancient gene considered one of the most important in cancer research.The p53 gene appears to be involved in signaling other cells instrumental in stopping tumor development. But the p53 gene predates cancer, so scientists are uncertain what its original function is.In trying to unravel the mystery, Dr.



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Scientists pinpoint neurons where select memories grow

Memories are difficult to produce, often fragile, and dependent on any number of factors - including changes to various types of nerves. In the common fruit fly - a scientific doppelganger used to study human memory formation - these changes take place in multiple parts of the insect brain.Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been able to pinpoint a handful of neurons where certain types of memory formation occur, a mapping feat that one day could help scientists predict disease-damaged neurons in humans with the same specificity.



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Potential target identified for treating mitochondrial disorders

Mitochondria, long known as "cellular power plants" for their generation of the key energy source adenosine triphosphate (ATP), are essential for proper cellular functions. Mitochondrial defects are often observed in a variety of diseases, including cancer, Alzheimer's disease, and Parkinson's disease, and are the hallmarks of a number of genetic mitochondrial disorders whose manifestations range from muscle weakness to organ failure. Despite a fairly strong understanding of the pathology of such genetic mitochondrial disorders, efforts to treat them have been largely ineffective.



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New diagnostic test for bowel diseases

A novel method for distinguishing different types of bowel disease using the stool samples of patients has been created by a group of researchers in the UK.It works by analysing the chemical compounds emitted from the samples and could provide cheaper, quicker and more accurate diagnoses, at the point of care, for a group of diseases that have, up until now, been very hard to distinguish.



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Closely observing the multiplication of cells

Our cells must grow and divide optimally to ensure that our bodies functions properly. It is essential, however, that these processes are carefully controlled in order to prevent unrestrained proliferation that can lead to the formation of tumours. David Shore, a professor at the Faculty of Sciences, University of Geneva (UNIGE), Switzerland, and his team have uncovered a cellular factor that regulates the timing of DNA replication. This molecule, called Rif1, ensures that only a fraction of the origins of DNA replication is activated at specified times of the cell cycle.



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Mitochondria affected in Gulf War illness

Researchers at the UC San Diego School of Medicine have demonstrated for the first time that veterans of the 1990-91 Persian Gulf War who suffer from "Gulf War illness" have impaired function of mitochondria - the energy powerhouses of cells.The findings, published in the journal PLOS ONE, could help lead to new treatments benefiting affected individuals - and to new ways of protecting servicepersons (and civilians) from similar problems in the future, said principal investigator Beatrice A. Golomb MD, PhD, professor of medicine.



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Study reports major advance in synthetic biology

An international team of scientists led by Jef Boeke, PhD, director of NYU Langone Medical Center's Institute for Systems Genetics, has synthesized the first functional chromosome in yeast, an important step in the emerging field of synthetic biology, designing microorganisms to produce novel medicines, raw materials for food, and biofuels.



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Risk of second stroke can be halved by consistent blood pressure control

Stroke survivors who consistently control their blood pressure may reduce the likelihood of a second stroke by more than half, according to new research in the American Heart Association journal Stroke.For the study, researchers analyzed the results from the Vitamin Intervention for Stroke Prevention (VISP) trial, which enrolled 3,680 ischemic stroke patients ages 35 and older in 1996-2003. Ischemic strokes are caused by a clot or other blockage in a blood vessel supplying the brain.



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Kidney disease caused by diabetes may be prevented by autoimmune drug

A drug currently used to treat autoimmune disease may also help prevent the kidney-damaging effects of diabetes, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings suggest that clinical trials should be designed to test the drug in diabetic patients.Kidney disease is one of the most serious complications of diabetes. Diabetics who develop kidney disease, or diabetic nephropathy, due to high blood glucose levels may eventually require dialysis or a kidney transplant.



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Risk of kidney failure in diabetics nearly doubled by major depression

Major depression may increase diabetes patients' risk of developing kidney failure, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). Additional studies are needed to determine whether treatment for depression can improve kidney health in patients with diabetes.Individuals with diabetes have a high prevalence of depressive symptoms, which has previously been linked with negative health outcomes such as cardiovascular disease and premature death.



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New tobacco plant produced therapeutics effective against West Nile virus, even days after infection

An international research group led by Arizona State University professor Qiang "Shawn" Chen has developed a new generation of potentially safer and more cost-effective therapeutics against West Nile virus, and other pathogens.The therapeutics, known as monoclonal antibodies (MAbs) and their derivatives, were shown to neutralize and protect mice against a lethal dose challenge of West Nile virus - even as late as 4 days after the initial infection.



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Improving understanding of circadian clock mechanisms

You've switched to the night shift and your weight skyrockets, or you wake at 7 a.m. on weekdays but sleep until noon on weekends - a social jet lag that can fog your Saturday and Sunday.Life runs on rhythms driven by circadian clocks, and disruption of these cycles is associated with serious physical and emotional problems, says Orie Shafer, a University of Michigan assistant professor of molecular, cellular and developmental biology.



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Congress budget pact good for global health but NIH cuts threaten US innovations

While a ceasefire in Washington's budget wars has restored funding for a range of programs targeting global health threats like AIDS and tuberculosis (TB), the simultaneous underfunding of the world's biggest sponsor of global health research and development (R&D) puts future progress at risk, warns a new report from a coalition of nonprofit groups focused on advancing innovation to save lives. The Global Health Technologies Coalition (GHTC) released their annual policy report at a Capitol Hill briefing.



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Gaming augments players' social lives

New research finds that online social behavior isn't replacing offline social behavior in the gaming community. Instead, online gaming is expanding players' social lives. The study was done by researchers at North Carolina State University, York University and the University of Ontario Institute of Technology."Gamers aren't the antisocial basement-dwellers we see in pop culture stereotypes, they're highly social people," says Dr. Nick Taylor, an assistant professor of communication at NC State and lead author of a paper on the study.



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Stronger kids have lower risks for diabetes and heart disease

It is well known that having good physical fitness lowers risks for a number of health problems. But now, the first study to make the link between strength capacity in adolescents and reduced risk for diabetes, heart disease or stroke has been published in the journal Pediatrics.Staying physically fit is an important value to instill in young people, not only because it creates healthy habits that can extend into adulthood, but also because it positively affects both short- and long-term health.



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Gene involved in carbohydrate digestion 'linked to obesity risk'

New research in the journal Nature Genetics suggests that there may be a genetic link between the way carbohydrates are digested and obesity."Previous genetic studies investigating obesity have tended to identify variations in genes that act in the brain and often result in differences in appetite, whereas our finding is related to how the body physically handles digestion of carbohydrates," first author Dr. Mario Falchi says.



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Statin use guidelines for cholesterol vary in US and Europe

Statins are commonly used to lower cholesterol, therefore helping to reduce the risk of cardiovascular disease. But new research finds that US and European cholesterol guidelines differ significantly when it comes to statin use recommendations, meaning many individuals may not be getting the correct treatment.This is according to a study recently published in the journal JAMA.Cardiovascular disease (CVD) is a main cause of death in the US. Main risk factors for the condition include high blood pressure, obesity and high cholesterol.



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Closure of coal plant in China led to improvements in children's health

Decreased exposure to air pollution in utero is linked with improved childhood developmental scores and higher levels of brain-derived neurotrophic factor (BDNF), a key protein for brain development, according to a study looking at the closure of a coal-burning power plant in China led by researchers at the Columbia Center for Children's Environmental Health at the Mailman School of Public Health.



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Unnecessary lung surgeries halved by preoperative PET

New quantitative data suggests that 30 percent of the surgeries performed for non-small cell lung cancer patients in a community-wide clinical study were deemed unnecessary. Additionally, positron emission tomography (PET) was found to reduce unnecessary surgeries by 50 percent, according to research published in the March issue of the Journal of Nuclear Medicine.PET imaging prior to surgery helps stage a patient's disease by providing functional images of tumors throughout the body, especially areas where cancer has spread, otherwise known as metastasis.



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Study reveals less invasive technique for vulvar cancer

A team of researchers from Women & Infants Hospital of Rhode Island's Program in Women's Oncology and Division of Pathology and Laboratory Medicine commanded a national stage to present the results of a study evaluating the use of sentinel lymph node dissection in women with vulvar malignancies, and then follow the patients for complications and recurrence.The team - Drs. Richard G. Moore, Dario Roque, Carolyn McCourt, Ashley Stuckey, Paul A.



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Patients with vitamin D deficiency at greater risk for more severe heart disease

Vitamin D deficiency is an independent risk factor for heart disease with lower levels of vitamin D being associated with a higher presence and severity of coronary artery disease, according to research presented at the American College of Cardiology's 63rd Annual Scientific Session.A growing body of research shows that vitamin D may be beneficial in preventing heart disease.



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Link discovered between clusters of 'broken hearts' and massive natural disasters

Dramatic spikes in cases of Takotsubo cardiomyopathy, also called broken heart syndrome, were found in two states after major natural disasters, suggesting the stress of disasters as a likely trigger, according to research to be presented at the American College of Cardiology's 63rd Annual Scientific Session. Authors call for greater awareness among emergency department physicians and other first responders.



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Strong association between Mediterranean diet and lower risk of diabetes

Adoption of a Mediterranean diet is linked to a lower risk of diabetes, especially among people at high risk for cardiovascular disease, according to research presented at the American College of Cardiology's 63rd Annual Scientific Session.Data from the first pooled analysis of studies evaluating the possible role of the Mediterranean diet on diabetes development show that adherence to this diet was associated with a 21 percent reduced risk of diabetes as compared to the control dietary groups.



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Seasonal fluctuations in cholesterol levels

Cholesterol levels fluctuate based on the time of year with more unfavorable lipid profiles seen in the colder months, a trend that may be driven by related behavior changes, according to research presented at the American College of Cardiology's 63rd Annual Scientific Session.While previous studies have shown that heart attacks and heart-related deaths increase during the winter months, researchers at Johns Hopkins Ciccarone Center for the Prevention of Heart Disease were interested in finding out whether cholesterol parameters might follow a similar pattern among a sample of 2.



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Gender differences in how the heart responds to exercise: findings challenge a long-held formula for peak heart rate

The formula for peak exercise heart rate that doctors have used for decades in tests to diagnose heart conditions may be flawed because it does not account for differences between men and women, according to research presented at the American College of Cardiology's 63rd Annual Scientific Session.The simple formula of "220 minus age" has been widely used to calculate the maximum number of heart beats per minute a person can achieve. Many people use it to derive their target heart rate during a workout.



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Cardiovascular disease, related deaths drop after Michigan implements public smoking ban

A new study on the impact of Michigan's statewide smoking ban adds to mounting evidence that policies prohibiting tobacco smoking in workplaces and other public spaces may substantially improve public health by reducing heart disease and death, according to research presented at the American College of Cardiology's 63rd Annual Scientific Session.Studies on previous indoor smoking bans have consistently shown a major decrease in hospital admissions for heart attacks after smoke-free laws went into effect. Secondhand smoke exposure is associated with an estimated 50,000 deaths among U.S.



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Hospital readmission for asthma increased by air pollution from traffic

Higher exposure to traffic-related air pollution (TRAP) dramatically increases the odds of readmission to the hospital for asthma - but only for white children, according to a new Cincinnati Children's Hospital Medical Center study.The study shows that white children exposed to high levels of TRAP are three times more likely to be readmitted for asthma than white children with low TRAP exposure. Levels of TRAP exposure were not associated with increased risk of readmission of black children, despite their having overall higher rates of asthma readmission than white children.



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Cereal flake size can influence your calorie intake, researchers warn

How is it possible to eat more cereal than you normally would, by putting less cereal in your bowl? It sounds like a riddle, but researchers at Penn State University have made this a focal point of their nutritional investigations.National dietary guidelines define recommended amounts of food in volume measures, such as cups. However, these measures do not account for other variations in food characteristics that affect nutritional intake and the amount of food we eat.



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College-aged drug users 'have impaired brain activity' linked to anticipation

New research from the University of California-San Diego School of Medicine has uncovered impaired neuronal activity in the brains of college-aged students who occasionally use stimulant drugs, such as amphetamines, cocaine and certain prescription drugs.The research team, led by Katia Harlé, PhD, recently published their findings in the Journal of Neuroscience.For their study, the investigators used functional magnetic resonance imaging (fMRI) to record the brain activity of 213 college students aged 18-24 years.



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Diabète: le cerveau à la rescousse

Des recherches, menées dans le nouveau Laboratoire de physiologie neurométabolique de l’Université de Fribourg, ont permis de découvrir une nouvelle voie de contrôle de la glycémie par le cerveau. Dans ce travail, réalisé en collaboration avec l’Université de Lausanne, le … Continue reading →

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Des vedettes de la LCF et de l’émission La Belle et la Bête donnent le coup d’envoi au 20(e) anniversaire de la marche venant en aide aux enfants atteints de diabète

Plus de 100 millions de dollars amassés à ce jour dans le cadre de la Marche pour la guérison du diabète TELUS TORONTO, le 27 mars 2014 /CNW/ – Joignez-vous à la Financière Sun Life et à FRDJ (anciennement la … Continue reading →

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Le projet VHP INTER@CTIVE : des seniors acteurs de leur santé

Le projet de VHP Inter@ctive vise à développer une offre de téléservices médico-sociaux-sanitaires bénéficiant aux seniors touchés par le diabète de type 2. L’ambition de ce projet est d’apporter une efficacité dans la prise en charge du patient diabétique sur … Continue reading →

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Plus d’un demi-siècle avec le diabète

À Jeanne Monfette et à Serge Gagnon, Novo Nordisk a remis la récompense Demi-Siècle, un «cadeau» particulier soulignant que ces deux personnes diabétiques vivent d’insuline depuis plus de 50 ans. Soixante-trois ans dans le cas de la dame de 87 … Continue reading →

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SANTÉ SPORT 92 : FAITES DU SPORT GRÂCE À L’ASSURANCE MALADIE !

La caisse d’Assurance Maladie des Hauts-de-Seine propose aux assurés du département présentant des signes de sédentarité et/ou souffrant de certaines pathologies : hypertension, obésité, diabète, cancers… de bénéficier, sur prescription médicale, d’un accès gratuit à des activités sportives. En favorisant … Continue reading →

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Pour que les femmes «continuent d’être bien» après un diabète gestationnel, l’hôpital et deux réseaux se mobilisent

« Avant, les femmes qui déclenchaient un diabète gestationnel étaient gérées durant la grossesse ; mais plus après leur accouchement… », résume l’un des médecins de l’hôpital Jean-Bernard. Oui, mais ça, c’était avant ! Désormais, l’établissement entend les aider à … Continue reading →

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Garder le poids gagné durant la grossesse est dangereux pour les mères

TORONTO – Les nouvelles mamans qui ne retrouvent pas au cours de la première année le poids qu’elles avaient avant la grossesse pourraient augmenter leurs risques de développer le diabète ou une maladie cardiaque, ou de subir un accident vasculo-cérébral … Continue reading →

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